Evaluation of Knowledge and Self-Awareness of Polish Soldiers Regarding Exposure to Chemical and Physical Factors in Their Place of Service/Work.

INTRODUCTION: Soldiers constitute a professional group carrying out their duties in variable, often challenging environmental conditions, including harmful and burdensome ones. MATERIALS AND METHODS: This study was conducted on a nationwide sample of 1331 soldiers. The research tool was an anonymous questionnaire comprising 48 questions. Descriptive statistics were used to describe the characteristics of the studied group. The chi-square test was employed to examine the relationship between variables. A 95% confidence interval was adopted, with a significance level of p = 0.05. RESULTS: One in four soldiers work with low and one in five with moderate exposure to harmful chemical factors. Almost 10% of respondents lack knowledge about the types of chemical factors present during their service. One in five soldiers work with low and one in eight with moderate exposure to ionizing radiation. Approximately 5% of survey participants lack knowledge about the types of physical factors. One in three soldiers are unaware of the carcinogenic and mutagenic effects of the aforementioned factors. CONCLUSIONS: The systematic enhancement of knowledge and awareness among army members will help minimize the consequences of exposure to harmful conditions.

Neighbour-stranger discrimination in an African wood dove inhabiting equatorial rainforest.

We investigated within- and between-individual song variation and song-based neighbour-stranger discrimination in a non-learning bird species, the blue-headed wood-dove (Turtur brehmeri), which inhabits lowland rainforests of West and Central Africa. We found that songs of this species are individually specific and have a high potential for use in individual recognition based on the time-frequency pattern of note distribution within song phrases. To test whether these differences affect behaviour, we conducted playback experiments with 19 territorial males. Each male was tested twice, once with the songs of a familiar neighbour and once with the songs of an unfamiliar stranger. We observed that males responded more aggressively to playback of a stranger's songs: they quickly approached close to the speaker and spent more time near it. However, no significant differences between treatments were observed in the vocal responses. In addition, we explored whether responses differed based on the song frequency of the focal male and/or that of the simulated intruder (i.e., playback), as this song parameter is inversely related to body size and could potentially affect males' decisions to respond to other birds. Song frequency parameters (of either the focal male or the simulated intruder) had no effect on the approaching response during playback. However, we found that the pattern of response after playback was significantly affected by the song frequency of the focal male: males with lower-frequency songs stayed closer to the simulated intruder for a longer period of time without singing, while males with higher-frequency songs returned more quickly to their initial song posts and resumed singing. Together, these results depict a consistently strong response to strangers during and after playback that is dependent on a male's self-assessment rather than assessment of a rival's strength based on his song frequency. This work provides the first experimental evidence that doves (Columbidae) can use songs for neighbour-stranger discrimination and respond according to a "dear enemy" scheme that keeps the cost of territory defence at a reasonable level.

Detection ranges of forest bird vocalisations: guidelines for passive acoustic monitoring.

Passive acoustic monitoring has proven to have many advantages for monitoring efforts and research activities. However, there are considerations to be taken into account regarding the placement of autonomous sound recorders. Detection ranges differ among species and in response to variable conditions such as weather or the location of vocalising animals. It is thus important to the success of a research project to understand, with a certain degree of confidence, the distances at which birds might be detected. In two types of forests in Poland, we played back the vocalisations of 31 species of European forest birds exemplifying different singing characteristics. Based on recordings obtained along a 500-m transect, we estimated the probability of detection and maximum detection distance of each vocalisation. We broadcasted the recording at three heights of singing and repeated playbacks three times during the breeding season to evaluate the effect of vegetation growth. Our results revealed that environmental and meteorological factors had a significant influence on both detection probability and maximum detection distances. This work provides comprehensive measurements of detection distance for 31 bird species and can be used to plan passive acoustic monitoring research in Europe, taking into account species traits and individual characteristics of the study area.

The Influence of Selected Laser Engraving Parameters on Surface Conditions of Hybrid Metal Matrix Composites.

Hybrid metal matrix composites (HMMCs) are a special type of material, possessing combined properties that belong to alloys and metals according to market demands. Therefore, they are used in different areas of industry and the properties of this type of material are useful in engineering applications, e.g., in aircraft engines and electrotechnical parts. The structure of the material requires a number of scientific studies to develop an appropriate processing technology. The paper presents the susceptibility of material from the HMMCs group with the EN AC-44300 (AISi12(Fe)) aluminum alloy matrix with a two-component reinforcement made of alumina particles (AP) and aluminosilicate fibers (AF) to thermal treatment with a laser beam. During this process, laser engraving of the researched material with variable beam power Pav and variable speed of the laser head vl were carried out. A metallographic analysis of the material was carried out. After laser engraving, surface structural changes of the material were determined. The properties of the surface geometric structure of processed material were also examined. Presented studies concern laser engraving on the surface of composite from the HMMC group, which was made by vacuum infiltration. Thanks to this method, it is possible both to produce shaped and precise composite castings with saturated reinforcement and to consequently minimize machining losses. Metal-ceramic composites from the HMMC group are hard-to-machine materials which create problems during machining. The aim of these studies was to develop a laser engraving technology with Al matrix composite with the addition of Al2O3 particles and aluminosilicate fibers, which constitute the reinforcement. The focus was on the selection of engraving parameters (beam power and speed of movement of the laser head). Clear examples of engraving, suitable for macro-assessment, were obtained with minimal change in the initial surface structure of the composite.

Response of forest Turtur doves to conspecific and congeneric songs in sympatry and allopatry.

Birds have a diverse acoustic communication system, and the ability to recognise their own species' song from a distance facilitates complex behaviours related to mate attraction and rival deterrence. However, certain species, including doves, do not learn songs and their vocal repertoires are much simpler than those of better-studied songbirds. In these so-called non-learning birds, relatively little is known about the role that bird song plays in intra- and interspecific interactions, and how such behaviours might be acquired (inherited or learned from experience). To investigate this question, we focused on two species of African wood doves whose long-range songs are used in a territorial context. Specifically, we examined the responses of sympatric and allopatric populations of male blue-headed wood-doves (Turtur brehmeri) and tambourine doves (Turtur tympanistria) to different types of simulated territorial intrusions, i.e. playback of conspecific, congeneric, and control songs. We aimed to assess (i) whether these species, which have similar songs, respond only to their own species' song or exhibit interspecific territoriality, and (ii) if the response pattern is affected by the presence or absence of congeners in the general area. We found that both species responded strongly to playback of their own species in both sympatric and allopatric populations. In allopatry, though, male tambourine doves misdirected their response and also approached the playback of congeneric songs. Our results indicate that, in areas where the studied Turtur doves live in sympatry, they do not exhibit consistent interspecific territoriality. However, we cannot exclude the possibility that the smaller tambourine dove avoids its larger congener during the process of territory establishment. The difference in tambourine doves' response toward the song of present (sympatric) or absent (allopatric) congeners suggests that the ability to discriminate between songs of similarly singing potential competitors is acquired through earlier interactions and learning. This plasticity in response supports the misdirected aggression hypothesis, which argues that interspecific territorialism emerges as a maladaptive by-product of signal similarity. However, on an evolutionary timescale, such an ability could be considered an adaptive cognitive tool useful for resolving competing interests with congeners.

Determination of Saturation Conditions of the Aluminum Metal Matrix Composites Reinforced with Al2O3 Sinter.

Aluminum metal matrix composites (Al MMCs) are a class of materials characterized by being light in weight and high hardness. Due to these properties, Al MMCs have various applications in the automobile, aeronautical and marine industries. Ceramic-reinforced Al MMCs in the form of sinters are known for having excellent abrasive properties, which makes them an attractive material in certain fields of technology. The biggest problem in their production process is their low ability to infiltrate ceramics with alloys and consequently the difficulty of filling a ceramic preform. The castability of such composites has not yet been researched in detail. The aim of this study was to create aluminum metal matrix composite castings based on aluminum alloys (AlSi11) reinforced with an Al2O3 sinter preform using a Castability Trials spiral mold, and then to determine the degree of saturation with the liquid metal of the produced ceramic shaped body (Castability Trials spiral). For the selected AlSi11 alloy, the liquidus (Tl) and solidus (Ts) temperatures were determined by performing thermal-derivation analysis during cooling, which is Tl-579.3 °C and Ts-573.9 °C. The resultant pressure necessary for the infiltration process was estimated for the reinforcement capillaries with the following dimensions: 10, 15, 20, 25, 30 and 35 microns. The following values were used to determine the capillary pressure (Pk): surface tension of the alloy-σ = 840 mN/m; the extreme wetting angle of the reinforcement by the metal-θ = 136°. It has been experimentally confirmed that for the vacuum saturation process, the estimated resultant pressure enables saturation of reinforcement with capillaries larger than 25 microns, provided that the alloy temperature does not drop lower than the infiltration temperature. After the experiment, the time and route of the liquid metal flow in the spiral were determined. On the basis of the obtained values, a simulation was developed and initial assumptions such as saturation time, alloy temperature, reinforcement and mold temperature were verified. The energy balance showed that the saturation limit temperature was Tk = 580.7 °C for the reinforcement temperature of 575 °C. In contrast to the above, the assumption that the temperature of the metal after equalizing the temperature of the composite components must be higher than the liquidus temperature (Tliq = 579.3 °C) for the aluminum alloy used must be fulfilled. After the experiment, the time and path of the liquid metal flow in the spiral were determined. Then, on the basis of the obtained values, a simulation was developed, and the initial assumptions (saturation time and temperature) were verified.

New cyclopentaquinoline and 3,5-dichlorobenzoic acid hybrids with neuroprotection against oxidative stress for the treatment of Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative brain disease. Thus, drugs including donepezil, rivastigmine, and galantamine are not entirely effective in the treatment of this multifactorial disease. The present study evaluates eight derivatives (3a-3h) as candidates with stronger anti-AD potential but with less side effects. Reactive oxygen species (ROS) assays were used to assess oxidative stress which involve in the neurodegeneration. The neuroprotective properties of 3e against oxidative stress were done in three experiments using MTT test. The anti-AD potential was determined based on their anticholinesterase inhibition ability, determined using Ellman's method, Aß aggregation potential according to thioflavin (Th) fluorescence assay, and their antioxidative and anti-inflammatory activities. Compound 3e exhibited moderate cholinesterase inhibition activity (AChE, IC50 = 0.131 µM; BuChE, IC50 = 0.116 µM; SI = 1.13), significant inhibition of Aß(1-42) aggregation (55.7%, at 5 µM) and acceptable neuroprotective activity. Extensive analysis of in vitro and in vivo assays indicates that new cyclopentaquinoline derivatives offer promise as candidates for new anti-AD drugs.

Comparison of reorganized versus unaltered cardiology departments during the COVID-19 era: A subanalysis of the COV-HF-SIRIO 6 study.

BACKGROUND: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, numerous cardiology departments were reorganized to provide care for COVID-19 patients. We aimed to compare the impact of the COVID-19 pandemic on hospital admissions and in-hospital mortality in reorganized vs. unaltered cardiology departments. METHODS: The present research is a subanalysis of a multicenter retrospective COV-HF-SIRIO 6 study that includes all patients (n = 101,433) hospitalized in 24 cardiology departments in Poland between January 1, 2019 and December 31, 2020, with a focus on patients with acute heart failure (AHF). RESULTS: Reduction of all-cause hospitalizations was 50.6% vs. 21.3% for reorganized vs. unaltered cardiology departments in 2020 vs. 2019, respectively (p < 0.0001). Considering AHF alone respective reductions by 46.5% and 15.2% were registered (p < 0.0001). A higher percentage of patients was brought in by ambulance to reorganized vs. unaltered cardiology departments (51.7% vs. 34.6%; p < 0.0001) alongside with a lower rate of self-referrals (45.7% vs. 58.4%; p < 0.0001). The rate of all-cause in-hospital mortality in AHF patients was higher in reorganized than unaltered cardiology departments (10.9% vs. 6.4%; p < 0.0001). After the exclusion of patients with concomitant COVID-19, the mortality rates did not differ significantly (6.9% vs. 6.4%; p = 0.55). CONCLUSIONS: A greater reduction in hospital admissions in 2020 vs. 2019, higher rates of patients brought by ambulance together with lower rates of self-referrals and higher all-cause in-hospital mortality for AHF due to COVID-19 related deaths were observed in cardiology departments reorganized to provide care for COVID-19 patients vs. unaltered ones.

Tool Wear and Surface Roughness in Turning of Metal Matrix Composite Built of Al2O3 Sinter Saturated by Aluminum Alloy in Vacuum Condition.

Metal matrix composites (MMCs) are a special class of materials carrying combined properties that belongs to alloys and metals according to market demands. Therefore, they are used in different areas of industry, and the properties of this type of material are useful in engineering applications. Machining of such composites is of great importance to finalize the fabrication process with improved part quality. However, the process implies several challenges due to the complexity of the cutting processes and random material structure. The current study aims to examine machinability characteristics. Effects of turning a metal matrix composite built of Al2O3 sinter, saturated with an EN AC-44000 AC-AlSi11 alloy, are presented in this paper. In the present study, a turning process of new metal matrix composites was carried out to determine the state-of-the-art material for various engineering applications. During the turning process, the cutting forces, a tool's wear, and surface roughness were investigated. Further, the SEM (scanning electron microscope) analysis of cutting inserts was performed. The influence of MMC structure on the machining process and surface roughness was studied. The Al2O3 reinforcements were used in different graininess. Effects of conventional turning of the metal matrix composite with Al2O3 sinter of FEPA (Federation of European Producers of Abrasives) 046 and FEPA 100 grade were compared. Results analysis of these tests showed the necessity of continuing research on turning metal matrix composites built of an AlSi alloy and Al2O3 ceramic reinforcement. The study showed the properties of MMCs that influenced machinability. In this paper, the influence of feed rate's value on surface roughness was carried out. The significant tool wear during the turning of the MMC was proved.

In Silico ADME and Toxicity Prediction of Benzimidazole Derivatives and Its Cobalt Coordination Compounds. Synthesis, Characterization and Crystal Structure.

As a result of the synthesis, three new solids, cobalt (II) coordination compounds with benzimidazole derivatives, and chlorides were obtained. The ligands that were used in the synthesis were specially synthesized and were commercially unavailable. During the synthesis, a single crystal of the complex with the L1 ligand was obtained and the crystal structure was refined. All coordination compounds were characterized by elemental analysis, infrared spectroscopy, and thermogravimetric analysis. All the obtained data allowed one to determine the formulas of the new compounds, as well as to determine the method of metal-ligand coordination. Thermal analysis allowed to know the temperature stability of the compounds, solids intermediate and final products of pyrolysis. Additionally, volatile decomposition and fragmentation products have been identified. The toxicity of the compounds and their bioavailability were determined using in silico methods. By predicting activity on cell lines, the potential use of compounds as chemotherapeutic agents has been specified. The blood-brain barrier crossing and the gastrointestinal absorption were defined. Pharmaceutical biodistribution was also simulated.

Male and female songs propagation in a duetting tropical bird species in its preferred and secondary habitat.

Acoustic signals produced by animals must transmit through the environment to reach potential receivers and change their behaviour. Both the environment (vegetation, air properties, other animals) and the form of the signal affect the propagation process. Here we investigated how the transmission of different song types of a duetting songbird species inhabiting an extreme environment within African montane forest, varies between males and females as well as different types of micro-habitats. We hypothesised that male and female songs would have different transmission properties, reflecting known differences in signal form and function. We analysed signal-to-noise ratio (SNR), excess attenuation (EA) and tail-to-signal ratio (TSR) of songs of male and female Yellow-breasted Boubous (Laniarius atroflavus) that were played and re-recorded in a range of sites representing the species-typical habitats. We found significant effects of distance, site (habitat) and sex reflected in all three measures of sound degradation. The clearest, primarily distance-dependent pattern was found for SNR of songs propagated in level forest site. EA was substantially higher in shrubs than in forest habitats, while TSR reflecting longer echoes appeared at longer distances in forest sites. Thus, Yellow-breasted Boubou songs are better propagated in forests than in disturbed sites covered with shrubs. We found that all male song types used for broadcast singing propagated farther than female songs, with significantly higher SNR at all distances. The different male song types which are known to have different functions, also demonstrated a differentiated pattern of propagation reflecting their functionality. All signals that were tested propagated the furthest in the ideal condition described as forest with a level terrain. Signals degraded much faster during transmission through shrubs regrowing after forest burning. On this site, the differences in the propagation of male and female songs, as well as the differences between male song types, were relatively least pronounced. Transmission in typical mountain forest among streams and with substantial terrain variation revealed that degradation pattern in such habitat could be perturbed in a non-linear way. Streams acting as a source of high noise level also negatively affected transmission and may strongly limit the perception of birds staying close to them. However, stream noise did not affect sex differences in song propagation as was found for the site located in shrubs. Male songs showed more efficient transmission through all habitats (least in the shrubs) than female song. These differences were the result of male songs having a whistle structure that is better adapted for long-range propagation than the atonal, wideband frequency female vocalisations. Results support the idea that signals of males of the Yellow-breasted Boubous evolved under the pressure of long-range communication both with rivals and females, while females of the species are much more focused on within-pair communication or signalling together with their partner. The consequence of deforestation resulting in pushing back territories to the forest remnants along streams may be a shortening of the song's active range, in particular, in females.

Lactoferrin-Conjugated Nanoparticles as New Antivirals.

Lactoferrin is an iron-binding glycoprotein with multiple functions in the body. Its activity against a broad spectrum of both DNA and RNA viruses as well as the ability to modulate immune responses have made it of interest in the pharmaceutical and food industries. The mechanisms of its antiviral activity include direct binding to the viruses or its receptors or the upregulation of antiviral responses by the immune system. Recently, much effort has been devoted to the use of nanotechnology in the development of new antivirals. In this review, we focus on describing the antiviral mechanisms of lactoferrin and the possible use of nanotechnology to construct safe and effective new antiviral drugs.

New Imaging Modality of COVID-19 Pneumonia Developed on the Basis of Alzheimer's Disease Research.

Viral pneumonia caused by highly infectious SARS-CoV-2 poses a higher risk to older people and those who have underlying health conditions, including Alzheimer's disease. In this work we present newly designed tacrine-based radioconjugates with physicochemical and biological properties that are crucial for the potential application as diagnostic radiopharmaceuticals. A set of ten tacrine derivatives was synthesized, labelled with gallium-68 and fully characterized in the context of their physicochemical properties. Based on these results, the final two most promising radioconjugates, [68Ga]Ga-NODAGA-Bn-NH(CH2)9Tac and [68Ga]Ga-THP-NH(CH2)9Tac, were selected for biodistribution studies. The latter compound was proven to be a good inhibitor of cholinesterases with significant affinity toward the lungs, according to the biodistribution studies. On the basis of molecular modelling combined with in vitro studies, we unraveled which structural properties of the developed tacrine derivatives are crucial for high affinity toward acetylcholinesterase, whose increased levels in lung tissues in the course of coronavirus disease indicate the onset of pneumonia. The radiopharmaceutical [68Ga]Ga-THP-NH(CH2)9Tac was ultimately selected due to its increased accuracy and improved sensitivity in PET imaging of lung tissue with high levels of acetylcholinesterase, and it may become a novel potential diagnostic modality for the determination of lung perfusion, including in inflammation after COVID-19.

Ion channel inhibition with amiodarone or verapamil in symptomatic hospitalized nonintensive-care COVID-19 patients: The ReCOVery-SIRIO randomized trial.

BACKGROUND: Ion channel inhibition may offer protection against coronavirus disease 2019 (COVID-19). Inflammation and reduced platelet count occur during COVID-19 but precise quantification of risk thresholds is unclear. The Recov ery-SIRIO study aimed to assess clinical effects of amiodarone and verapamil and to relate patient phenotypes to outcomes. METHODS: RECOVERY-SIRIO is a multicenter open-label 1:1:1 investigator-initiated randomized trial with blinded event adjudication. A sample of 804 symptomatic hospitalized nonintensive-care COVID-19 patients, follow-up for 28 days was initially planned. RESULTS: The trial was stopped when a total of 215 patients had been randomized to amiodarone (n = 71), verapamil (n = 72) or standard care alone (n = 72). At 15 days, the hazard ratio (hazard ratio [HR], 95% confidence interval [CI]) for clinical improvement was 0.77 (0.52-1.14) with amiodarone and 0.97 (0.81-1.17) with verapamil as compared to usual care. Clinically relevant associations were found between mortality or lack of clinical improvement and higher peak C-reactive protein (CRP) levels or nadir platelet count at 7, 10 and 15 days. Mortality rate increased by 73% every 5 mg/dL increment in peak CRP (HR 1.73, 95% CI 1.27-2.37) and was two-fold higher for every decrement of 100 units in nadir platelet count (HR 2.19, 95% CI 1.37-3.51). By cluster analysis, thresholds of 5 mg/dL for peak CRP and 187 × 103/mcL for nadir platelet count identified the phenogroup at greatest risk of dying. CONCLUSIONS: In this randomized trial, neither amiodarone nor verapamil were found to significantly accelerate short-term clinical improvement. Peak CRP and nadir platelet counts were associated with increased mortality both in isolation and by cluster analysis.

Current Trends in Wick Structure Construction in Loop Heat Pipes Applications: A Review.

Thermal control systems have been introduced as an important part of electronic devices, enabling thermal management of their electronic components. Loop heat pipe (LHP) is a passive two-phase heat transfer device with significant potential for numerous applications, such as aerospace applications, high-power LEDs, and solar central receivers. Its advantages are high heat transfer capability, low thermal resistance, long-distance heat transfer, and compact structure. The essential role of wick structures on the performance of LHPs has already been highlighted, but no comprehensive review is available that deals with different parameters such as LHP design and wick size, which are largely decisive and effective in achieving a practical level of thermal transmission governed by wick structures. To rely on this necessity, this article summarizes, analyzes, and classifies advancements in the design and fabrication of wick structures. The main conclusion to be drawn after careful monitoring and weighing of the related literature is that LHPs with composites and additively manufactured wicks show a higher heat transfer coefficient than other conventional structures. Indeed, future works should be focused on the design of more structurally efficient wicks, which may allow us to optimize materials and geometrical parameters of wick structure for higher heat transfer through LHPs.

New Derivatives of 5-((1-Methyl-Pyrrol-2-yl) Methyl)-4-(Naphthalen-1-yl)-1,2,4-Triazoline-3-Thione and Its Coordination Compounds with Anticancer Activity.

A new ligand 5-((1-methyl-pyrrol-2-yl) methyl)-4-(naphthalen-1-yl)-1,2,4-triazoline-3-thione (C15) and its metal complexes with formulae: Mn(C15)Cl2MeOH (1), Fe(C15)Cl2MeOH (2), Ni(C15)Cl2MeOH (3), Cu(C15)2Cl2 (4) and Zn(C15)4Cl2 (5) have been synthesized. The C15 ligand and complexes were characterized by NMR, elemental analysis, FT-IR, EPR, magnetic and TGA studies. The anticancer activities of the organic ligand (C15) and complexes (1-5) were evaluated against human colon adenocarcinoma (HT29) and human lung (A549) cancer cell lines. The complex (1) exhibited potential activity at concentration of 794.37 µM (A549) and 654.31 µM (HT29) in both cancer cells. The complex (3) showed significant activity against the HT29 cancer cell line with an IC50 value of 1064.05 µM. This article highlights some of the metals that have become important in the development of new coordination complexes and the treatment of cancer. Additionally, for C15, the toxicity was predicted by ADMET analysis and molecular docking.

Synthesis and Biological Studies of Novel Aminophosphonates and Their Metal Carbonyl Complexes (Fe, Ru).

The quest to find new inhibitors of biologically relevant targets is considered an important strategy to introduce new drug candidates for the treatment of neurodegenerative diseases. A series of (aminomethyl)benzylphosphonates 8a-c and their metallocarbonyl iron 9a-c and ruthenium 10a-c complexes were designed, synthesized, and evaluated for their inhibitory potentials against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by determination of IC50. Metallocarbonyl derivatives, in general, did not show significant inhibition activity against these enzymes, the most potent inhibitor was the (aminomethyl)benzylphosphonate 8a (IC50 = 1.215 µM against AChE). Molecular docking analysis of AChE and (aminomethyl)benzylphosphonates 8a-c showed the strongest interactions of 8a and AChE compared to isomers 8b and 8c. Cytotoxicity studies of synthesized compounds towards the V79 cell line were also performed and discussed.

Revisional operations among patients after surgical treatment of obesity: a multicenter Polish Revision Obesity Surgery Study (PROSS).

Introduction: Revisional surgery is more technically challenging and associated with increased morbidity and mortality. Nevertheless, the frequency of revisional bariatric surgery (RBS) is increasing. Therefore, investigating this group of patients appears to be currently valid. Aim: The objective of this multicenter study was to collect, systematize and present the available data on RBS after surgical treatment of morbid obesity among Polish patients. Material and methods: This multicenter study included a retrospective analysis of a prospectively maintained database. Outcomes included an analysis of the indications for RBS, the type of surgery most frequently chosen as RBS and the course of the perioperative period of treatment among patients undergoing RBS. Results: The group consisted of 799 patients (624 (78.1%) women, 175 (21.9%) men). The mean age was 38.96 ±9.72 years. Recurrence of obesity was the most common indication for RBS. The most frequently performed RBS procedures were one anastomosis gastric bypass (OAGB) - 294 (36.8%) patients, Roux-en-Y gastric bypass (RYGB) - 289 (36.17%) patients and sleeve gastrectomy (SG) - 172 (21.52%) patients. After primary surgery 63.58% of patients achieved sufficient weight loss, but after RBS only 38.87%. Complications were noted in 222 (27.78%) cases after RBS with GERD being the most common - 117 (14.64%) patients. Conclusions: RBS most often concerns patients after SG. The main indication for RBS is weight regain. OAGB and RYGB were the two most frequently chosen types of RBS. Secondary operations lead to further weight reduction. However, RBS are associated with a significant risk of complications.

Novel Cyclopentaquinoline and Acridine Analogs as Multifunctional, Potent Drug Candidates in Alzheimer's Disease.

A series of new cyclopentaquinoline derivatives with 9-acridinecarboxylic acid and a different alkyl chain length were synthesized, and their ability to inhibit cholinesterases was evaluated. All designed compounds, except derivative 3f, exhibited a selectivity for butyrylcholinesterase (BuChE) with IC50 values ranging from 103 to 539 nM. The 3b derivative revealed the highest inhibitory activity towards BuChE (IC50 = 103.73 nM) and a suitable activity against AChE (IC50 = 272.33 nM). The 3f derivative was the most active compound to AChE (IC50 = 113.34 nM) with satisfactory activity towards BuChE (IC50 = 203.52 nM). The potential hepatotoxic effect was evaluated for both 3b and 3f compounds. The 3b and 3f potential antioxidant activity was measured using the ORAC-FL method. The 3b and 3f derivatives revealed a significantly higher antioxidant potency, respectively 35 and 25 higher than tacrine. Theoretical, physicochemical, and pharmacokinetic properties were calculated using ACD Labs Percepta software. Molecular modeling and kinetic study were used to reveal the mechanism of cholinesterase inhibition in the most potent compounds: 3b and 3f.

Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes.

A novel biologically active thiosemicarbazide derivative ligand L (N-[(phenylcarbamothioyl)amino]pyridine-3-carboxamide) and a series of its five metal(II) complexes, namely: [Co(L)Cl2], [Ni(L)Cl2(H2O)], [Cu(L)Cl2(H2O)], [Zn(L)Cl2] and [Cd(L)Cl2(H2O)] have been synthesized and thoroughly investigated. The physicochemical characterization of the newly obtained compounds has been performed using appropriate analytical techniques, such as 1H and l3C nuclear magnetic resonance (NMR), inductively coupled plasma (ICP), thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR) and magnetic measurements. In order to study the pharmacokinetic profile of the compounds, ADMET analysis was performed. The in vitro studies revealed that the synthesized compounds exhibit potent biological activity against A549 human cancer cell line.